Related Experiment Video
Updated: Aug 13, 2026
02:28
Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Association between adiposity and psoriatic arthritis beyond classical clinical predictors
Estefanía Pardo1, Stefanie Burger1, Marta Loredo1
1Rheumatology Division, Hospital Universitario Central de Asturias, Oviedo, Spain.
Clinical Rheumatology
|August 11, 2026
Summary
Adiposity, or excess body fat, is independently linked to psoriatic arthritis (PsA). Higher levels of adiposity show a graded association with PsA, suggesting a connection between metabolic health and joint inflammation in psoriatic disease.
Area of Science:
- Rheumatology
- Dermatology
- Metabolic Health
Background:
- Psoriatic arthritis (PsA) affects a significant number of psoriasis patients.
- While obesity is linked to PsA, the independent role of adiposity in increasing joint risk is not fully understood.
Purpose of the Study:
- To investigate if adiposity has a graded association with PsA across various clinical presentations.
- To determine the independent contribution of adiposity to PsA risk.
Main Methods:
- Cross-sectional study of 519 psoriatic disease cases, with 27.2% having PsA.
- Logistic regression models assessed waist circumference and BMI association with PsA, adjusting for psoriasis duration, nail involvement, PASI, and sex.
- Explored interactions between adiposity and established PsA predictors; model discrimination assessed via AUC.
Main Results:
- Nail involvement and longer psoriasis duration were strongest predictors of PsA.
- A graded association was observed with increasing waist circumference quartiles (aOR per quartile increase 1.28).
- Body mass index (BMI) showed similar associations; no significant interactions found between adiposity and psoriasis duration/severity, though potential differences based on nail involvement were noted.
Conclusions:
- Adiposity is independently associated with PsA and demonstrates a graded relationship.
- Findings suggest a link between metabolic burden and the expression of joint disease in psoriatic disease.
- Adiposity may play a significant role in the development or exacerbation of PsA.
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