A Redox-Responsive Nanoplatform Modulating the Treg/Th17 Balance Through LAT1- and PPARγ-Related Pathways for...

Area of Science:

• Immunology
• Dermatology
• Nanotechnology

Background:

• Psoriasis affects 2-3% globally, requiring safer, more effective treatments due to limitations of current therapies.
• Restoring regulatory T (Treg) and T helper 17 (Th17) cell balance is a key strategy for psoriasis treatment.
• Existing psoriasis therapies have limited efficacy, cause skin irritation, or have serious side effects.

Purpose of the Study:

• To develop a redox-responsive nanoparticle-based hydrogel for topical psoriasis treatment.
• To co-deliver morin and JPH203 to modulate the Treg/Th17 balance in psoriatic skin.
• To create a safe and effective immunotherapeutic strategy for psoriasis.

Main Methods:

• Developed a redox-responsive nanoparticle hydrogel (PB-MJ@N/G) co-delivering morin and JPH203.
• Utilized PLA nanoparticles coated with bilirubin-conjugated poly-L-lysine for drug delivery.
• Investigated in vitro and in vivo models to assess Treg/Th17 ratio restoration and anti-psoriatic effects.

Main Results:

• The nanoparticle hydrogel successfully restored the Treg/Th17 ratio in psoriatic models.
• PB-MJ@N significantly alleviated psoriatic inflammation.
• The treatment attenuated lesion development in a psoriasis recurrence model.

Conclusions:

• The developed topical, stimuli-responsive nanoparticle hydrogel is a promising immunotherapeutic strategy for psoriasis.
• This approach offers sustained treatment benefits for psoriasis patients.
• The nanoparticle system demonstrates potential for enhanced local drug delivery and efficacy.