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MOF on HOF NanoFilms for Efficient Bacteria Infected Wound Healing
Haonan Jia1, Yujia Liu1, Rabia Sultan1
1School of Life Sciences, Shanghai University, Shanghai, China.
Advanced Healthcare Materials
|August 12, 2026
Summary
New gauze dressings combine metal-organic frameworks (MOFs) and hydrogen-bonded organic frameworks (HOFs) to fight antibiotic-resistant bacteria and promote wound healing. This advanced material shows high efficacy against Staphylococcus aureus and accelerates tissue repair.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- Antibiotic-resistant bacterial infections pose a significant threat, demanding novel wound care solutions.
- Porous organic frameworks offer unique properties for advanced wound dressings.
- Developing materials with both antimicrobial and tissue-regenerative capabilities is crucial.
Purpose of the Study:
- To develop and evaluate a novel wound dressing integrating MOF and HOF nanofilms on medical gauze.
- To assess the synergistic antibacterial and tissue repair capabilities of the MOF-on-HOF composite dressing.
- To investigate the efficacy of the MOF-on-HOF@guaze in an infected wound model.
Main Methods:
- Fabrication of MOF-on-HOF nanofilms via van der Waals heterojunction interactions.
- Uniform loading of the MOF-on-HOF composite onto medical gauze using solution processability and interfacial film formation.
- Evaluation of antibacterial activity against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA).
- Assessment of hemostasis, reactive oxygen species (ROS) scavenging, and cell migration promotion.
- In vivo testing on an MRSA-infected wound model to evaluate bacterial load reduction, cytokine expression, and wound closure rate.
Main Results:
- The MOF-on-HOF@guaze dressing demonstrated rapid and efficient elimination of Gram-positive pathogens, achieving >99% efficacy against Staphylococcus aureus.
- The dressing facilitated hemostasis, scavenged ROS, and accelerated cell migration, contributing to tissue repair.
- In an MRSA-infected wound model, the dressing eradicated bacteria, reduced pro-inflammatory cytokines, and promoted significant wound closure (98% healing rate).
Conclusions:
- The MOF-on-HOF@guaze represents a promising next-generation wound dressing with potent antibacterial activity and enhanced wound regeneration.
- This composite material offers a viable strategy for managing infected wounds and combating the challenge of antimicrobial resistance.
- The synergistic effects of MOF and HOF integration provide a robust platform for advanced wound care applications.
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