MOF on HOF NanoFilms for Efficient Bacteria Infected Wound Healing

The increasing severity of antibiotic-resistant bacterial infections necessitates the development of next-generation wound dressings capable of both potent antimicrobial activity and effective tissue repair. Porous organic framework materials possess stable structural connectivity, large specific surface areas, and well-ordered pore architectures, making them promising platforms for applications in infectious wound healing. In this study, metal-organic framework (MOF) and hydrogen-bonded organic framework (HOF) nanofilms (MOF-on-HOF) were successfully integrated onto medical gauze through van der Waals heterojunction interactions, enabling a synergistic cascade effect that enhances both antibacterial activity and wound regeneration. The MOF-on-HOF composite was uniformly loaded on gauze by utilizing the solution processability of HOF and the interfacial film-forming ability of MOF. The resulting MOF-on-HOF dressing rapidly and efficiently eliminated Gram-positive pathogens, thus demonstrating excellent antibacterial efficacy against Staphylococcus aureus (≥99%). Meanwhile, it facilitated hemostasis, scavenges reactive oxygen species (ROS), and accelerates cell migration. In a methicillin-resistant Staphylococcus aureus (MRSA)-infected wound model, treatment with MOF-on-HOF@guaze eradicated bacterial load on the wound surface, hence reduces the expression of pro-inflammatory cytokines, and significantly promotes wound closure, achieving a wound healing rate of 98%. These results highlight the MOF-on-HOF@guaze as a promising platform for managing acutely infected wounds and combating antimicrobial resistance.