Emerging Trends and Hot Spots in Tauopathy Research (2003-2025): A Bibliometric Analysis

Area of Science:

• Neuroscience
• Biomedical Research
• Bibliometrics

Background:

• Tauopathy research is critical for understanding neurodegenerative diseases like Alzheimer's.
• Tracking research trends is essential for guiding future scientific inquiry.

Purpose of the Study:

• To systematically analyze the evolution of tauopathy research from 2003 to 2025.
• To map the global research landscape and identify thematic shifts in tauopathy studies.

Main Methods:

• Bibliometric analysis of 6752 publications from Web of Science Core Collection (2003-2025).
• Utilized R package bibliometrix and VOSviewer for network analysis (co-authorship, co-citation, keyword co-occurrence).
• Employed Scimago Graphica for visualizing international collaboration.

Main Results:

• A marked increase in annual publications indicates sustained global interest in tauopathy.
• The United States leads in publication output and citation impact; University of Pennsylvania is a key institution.
• Research themes evolved from mechanistic studies to integrative topics like tau-amyloid interactions, neurodegeneration, and glial roles.

Conclusions:

• Bibliometric analysis offers a quantitative overview of the global tauopathy research landscape.
• The study captures the dynamic evolution of research priorities and identifies emerging directions in tauopathy.
• Provides a data-driven foundation for future tauopathy research endeavors.