Oral Manifestations of Sweet Syndrome in a Child: A Case Report

Sweet syndrome is a relatively rare disease characterized by neutrophilia, tender and erythematous skin lesions with sudden onset of fever. Oral involvement is usually rare. We report a case of a 5-year-old boy who presented with fever, spontaneous erythematous swelling over the right periorbital and suprasternal region, upper left lip swelling, generalized gingival hyperplasia over the upper gingiva, and a single ulcer on the right soft palate region. Blood results was consistent with bicytopenia and leukocytosis, while biopsy of the skin and gingival lesions revealed dense infiltration of mixed inflammatory cells composed predominantly of neutrophils. Sweet syndrome was suggested based on the clinical presentations and histological features. Steroid treatment was initiated according to the suggested protocol; unfortunately, the child's condition started to deteriorate 3 weeks after his initial presentation, and he passed away 2 weeks later due to massive intracranial bleeding. Proper investigation and screening are crucial when any oral lesions with unknown causes are encountered.