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Engineered Nature-Based Sonosensitizer for Broad-Spectrum Infectious Tissue Repair via Sono-Ionic Therapy
Liang Ma1, Hongchuan Wang1, Weidong Liang2
1Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Exploration (Beijing, China)
|August 12, 2026
Summary
This study introduces a novel hemoglobin-based sonosensitizer for treating infectious tissues. It effectively clears biofilms and promotes tissue repair via sono-ionic therapy, offering a promising new treatment for bone and wound infections.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Regenerative Medicine
Background:
- Infectious tissue repair, especially bone and wound infections, presents significant clinical challenges due to limited effective treatments.
- Sonodynamic therapy (SDT) uses sonosensitizers to generate reactive oxygen species (ROS) for antibacterial effects, but lacks biocompatible agents that also promote tissue repair.
- Current treatment modalities struggle to effectively address both infection clearance and subsequent tissue regeneration.
Purpose of the Study:
- To develop and evaluate a novel, biocompatible sonosensitizer for treating infectious tissues.
- To investigate the dual therapeutic potential of the sonosensitizer for antibacterial action and tissue repair.
- To explore the underlying mechanisms of tissue repair induced by the developed therapeutic platform.
Main Methods:
- A novel sonosensitizer was constructed using hemoglobin and zeolitic imidazolate framework (ZIF)-8.
- High-power ultrasound (US) was used for ROS generation (antibacterial), and low-power US for sono-ionic therapy (tissue repair).
- Therapeutic efficacy was assessed in bone, wound infection, and wound biofilm models using microneedle-assembled nanoparticles and bioadhesive hydrogels.
Main Results:
- The hemoglobin-ZIF-8 sonosensitizer demonstrated excellent biocompatibility and activity.
- The platform achieved deep biofilm clearance and effective antibacterial action via ROS generation.
- Sono-ionic therapy significantly promoted tissue repair, identified through RNA sequencing to involve the peroxisome proliferator-activated receptor signaling pathway.
Conclusions:
- The developed hemoglobin-ZIF-8 sonosensitizer offers a dual-action therapeutic strategy for infectious tissue repair.
- The platform effectively addresses both bacterial infection and promotes subsequent tissue regeneration.
- This novel approach shows significant potential for broad-spectrum treatment of various infectious tissue conditions.
