Related Experiment Video
Updated: Aug 13, 2026
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Ultrasonic flow ratio versus Murray law-based quantitative flow ratio for predicting target vessel failure after
Jingao Jiang1, Ziyi Yan1, Wenhao Huang2
1The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Abstract:
Residual ischemia after percutaneous coronary intervention (PCI) is closely associated with adverse clinical outcomes. Murray law-based quantitative flow ratio (μQFR), derived from coronary angiography, has demonstrated prognostic value after PCI. Ultrasonic flow ratio (UFR), derived from intravascular ultrasound (IVUS), integrates intravascular imaging with computational physiological assessment; however, its prognostic performance relative to μQFR in patients undergoing IVUS-guided PCI remains insufficiently defined. This retrospective single-center study included 127 patients who underwent IVUS-guided PCI at the Sandun Campus of Zhejiang Hospital between January 2021 and December 2022 and completed follow-up coronary angiography during the follow-up period. UFR and μQFR were measured at the distal exit of the most distal stent. The primary endpoint was target vessel failure (TVF). Receiver operating characteristic curve analysis and Cox proportional hazards regression were performed. Among the 127 included patients, 19 developed TVF and 108 remained free of TVF. Compared with the non-TVF group, the TVF group had significantly lower minimum stent expansion rate, mean stent expansion rate, and post-PCI UFR. UFR showed the highest discriminatory ability for TVF and significantly outperformed μQFR. In multivariable analysis, only post-PCI UFR remained independently associated with TVF. These findings suggest that IVUS-derived anatomical-functional assessment may provide additional value for post-PCI risk stratification.
Insights
Ultrasonic flow ratio (UFR) derived from intravascular ultrasound (IVUS) better predicts adverse outcomes after percutaneous coronary intervention (PCI) than quantitative flow ratio (μQFR). UFR offers improved risk stratification for patients undergoing IVUS-guided PCI.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Imaging
Background:
- Residual ischemia post-percutaneous coronary intervention (PCI) is linked to poor clinical outcomes.
- Quantitative flow ratio (μQFR) from coronary angiography shows prognostic value.
- Intravascular ultrasound (IVUS) derived ultrasonic flow ratio (UFR) combines imaging with physiology, but its prognostic role versus μQFR after IVUS-guided PCI needs clarification.
Purpose of the Study:
- To compare the prognostic performance of ultrasonic flow ratio (UFR) and quantitative flow ratio (μQFR) in patients undergoing IVUS-guided PCI.
- To assess the independent association of UFR with target vessel failure (TVF) post-PCI.
Main Methods:
- Retrospective single-center study of 127 patients who underwent IVUS-guided PCI.
- Measurement of UFR and μQFR at the distal stent edge.
- Primary endpoint: target vessel failure (TVF).
- Statistical analysis included ROC curve analysis and Cox regression.
Main Results:
- The TVF group (19 patients) had lower minimum/mean stent expansion and post-PCI UFR compared to the non-TVF group (108 patients).
- UFR demonstrated superior discriminatory ability for TVF compared to μQFR.
- Post-PCI UFR was the sole independent predictor of TVF in multivariable analysis.
Conclusions:
- IVUS-derived anatomical-functional assessment using UFR provides significant value for post-PCI risk stratification.
- UFR outperforms μQFR in predicting TVF after IVUS-guided PCI.
- UFR may enhance clinical decision-making in interventional cardiology.
