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Updated: Aug 13, 2026
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Efficacy and safety of renal denervation in patients with refractory ventricular electrical storm
Guanghui Zhu1,2, Xuelian Yuan1,2, Yangpeng Li1,2
1Cardiac Pacing and Electrophysiology Department, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Background:
Ventricular electrical storm (ES) is a malignant arrhythmia that seriously threatens the patients' life. Renal denervation (RDN) has been described as a treatment modality for refractory ventricular arrhythmias. This study aims to explore the potential role in patients with ablation-refractory ES.
Methods:
This single-center retrospective cohort study included patients with refractory ES who underwent RDN between 2023 and 2024 with a follow-up period for 2-6 months. Implantable cardioverter defibrillator (ICD) programming results and intraoperative parameters were collected. Patients' clinical examination results were also compiled.
Results:
The study involved 10 patients with a mean age of 57.9 ± 7.4 years, including 4 (40%) ischemic cardiomyopathy, 6 (60%) dilated cardiomyopathy and 6 (60%) hypertension. ICD therapies showed a decreasing trend after multimodal therapy including RDN [pre-RDN 22 [9.3, 41], post-RDN 2.5 [0, 26.3]]. ICD shock therapies exhibited a similar descending tendency [pre-RDN 8.5 [1, 12.8] and post-RDN 0.5 [0, 3.5]]. Echocardiography and plasma results remained unchanged before and after surgery, including ejection fraction, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, and creatinine concentration.
Conclusion:
Multimodal therapy including RDN may has the potential to contribute to decrease ICD therapies for patients with ES. Larger sample investigations may further demonstrate the efficacy and safety of RDN.
