Clinical evaluation of the effectiveness of laser localization system in CT-guided percutaneous lung puncture...

Computed tomography (CT)-guided percutaneous lung biopsy localization plays a pivotal role in the diagnosis and management of thoracic diseases. The present study aimed to investigate and compare a laser localization system with traditional puncture technology, focusing on their accuracy and safety in clinical practice.

A total of 120 patients who required preoperative CT-guided percutaneous lung nodule localization between October 2023 and October 2024 were prospectively enrolled. Among them, 60 patients who underwent puncture under CT guidance with the assistance of a laser locator were assigned to the observation group, and 60 patients who received conventional CT-guided puncture were allocated to the control group. Adverse reactions related to percutaneous lung puncture were recorded according to the Common Terminology Criteria for Adverse Events (CTCAE 5.0). The puncture time, average number of CT scans, one-time puncture success rate, and incidence of complications were compared between the two puncture methods.

The average diameter of lung nodules in the observation group was 0.85±0.38 cm, with a one-time puncture success rate of 93.3% (56/60); in the control group, the average diameter of lung nodules was 0.87±0.31 cm, and the one-time puncture success rate was 83.3% (50/60). Compared with the control group, the observation group had fewer average CT scans (3.53±1.40 vs. 5.80±1.56 times), shorter puncture time (7.63±3.51 vs. 11.00±5.31 min), and lower radiation dose (45.81±12.41 vs. 65.28±15.16 mSv), with statistically significant differences (all P<0.05). When comparing the puncture errors of nodules in different lung lobe locations between the two groups, the results showed that in the observation group, the puncture error for lower lobe nodules was significantly greater than that for non-lower lobe nodules (2.48±0.65 vs. 1.90±0.31 mm, P<0.05); similarly, in the control group, the puncture error for lower lobe nodules was also greater than that for non-lower lobe nodules (3.61±1.72 vs. 2.58±0.52 mm, P<0.05).

The laser locator-assisted CT-guided percutaneous lung biopsy yields favorable procedural outcomes, with shorter operation time, fewer repeated scans and lower radiation exposure. Although no significant difference was found in the one-time puncture success rate versus the conventional method, this auxiliary localization system shows promising clinical value. Further large-scale multicenter trials are required to validate its efficacy and routine clinical applicability.