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Biomedical PCL Janus patch with mushroom-structured wet adhesive and PEG-coated anti-adhesive surface
Shinyull Lee1,2,3, Woochan Kim1,2,3, Harshita Sharma1,2,3
1Department of Convergence Biosystems Engineering, Chonnam National University Gwangju 61186 Republic of Korea rain2000@jnu.ac.kr.
RSC Advances
|August 12, 2026
Summary
This study presents a novel Janus patch combining tissue adhesion and anti-adhesion. The patch utilizes mushroom microstructures for wet adhesion and PEG coating for anti-adhesion, overcoming a key challenge in biomedical patch development.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Surface Chemistry
Background:
- Developing biomedical patches with both adhesive and anti-adhesive properties is challenging.
- Existing materials often struggle to achieve spatially distinct functions on a single platform.
Purpose of the Study:
- To engineer a PCL-based Janus patch with simultaneous wet adhesion and anti-adhesion capabilities.
- To address the limitations of current biomedical patch technologies.
Main Methods:
- Fabrication of a PCL-based Janus patch utilizing mushroom-shaped microstructures for adhesion.
- Application of UV-crosslinked polyethylene glycol (PEG) to create an anti-adhesive surface.
- Characterization of the patch's adhesive and anti-adhesive properties.
Main Results:
- The mushroom-structured surface demonstrated enhanced wet tissue adhesion.
- The PEG-coated surface effectively reduced nonspecific fibroblast attachment.
- The Janus patch successfully achieved spatially separated adhesive and anti-adhesive functions.
Conclusions:
- The developed PCL-based Janus patch offers a promising solution for biomedical applications requiring localized adhesion and non-adhesion.
- This platform technology advances the design of multifunctional biomedical patches.
