Pediatric Central Giant Cell Granuloma in the Nasal Cavity: A Case Report and Literature Review

Central giant cell granuloma (CGCG) is a rare benign and locally aggressive osteolytic lesion that predominantly affects the mandible and maxilla in the head and neck region. Involvement of the nasal cavity is extremely uncommon in children, with only a few cases reported, and is typically managed via external or transoral surgical approaches. We report CGCG in a healthy 13-year-old girl presenting as an expansile lesion of the right nasal cavity with adjacent bony remodeling. Diagnosis was established through radiological and histopathologic evaluation. The tumor was resected entirely using an endoscopic endonasal technique without an external approach. The patient remained disease-free and asymptomatic at 36 months. This report is complemented by a concise literature review that addresses the pathogenesis, diagnostic considerations, and management strategies for CGCG. The case highlights the feasibility of a minimally invasive approach without external access for managing pediatric nasal CGCG. This technique achieved complete excision with excellent cosmetic and functional outcomes and is considered a safe alternative to more extensive surgical procedures.