Differentiated Thyroid Cancer Recurrence and Mortality Prognostic Factors: A Retrospective Cohort Study on 350 Adult...

Area of Science:

• Oncology
• Endocrinology
• Public Health

Background:

• Differentiated thyroid cancer (DTC) is the most common type of thyroid malignancy.
• Effective management of DTC requires understanding factors influencing recurrence and mortality.
• Thyroidectomy followed by radioactive iodine (RAI) ablation is a standard treatment for DTC.

Purpose of the Study:

• To investigate risk factors for recurrence and mortality in differentiated thyroid cancer patients.
• To identify demographic and clinical predictors of adverse outcomes after thyroidectomy and RAI ablation.
• To provide data for improved risk stratification and personalized treatment strategies in DTC management.

Main Methods:

• Retrospective cohort study of 350 DTC patients over 18 years old.
• Patients underwent total thyroidectomy and radioactive iodine (RAI) ablation.
• Ten-year follow-up data analyzed using univariate and multivariate logistic regression (SPSS v26).

Main Results:

• Recurrence rate was 26.9% and mortality rate was 4.9%.
• Significant risk factors for recurrence and death included older age, male sex, smoking, tumor size >4 cm, and regional lymph node involvement.
• Increased risk per year of age (4% recurrence, 9% mortality), male sex (5.111x recurrence), and smoking (6.002x mortality) were observed.

Conclusions:

• Timely diagnosis and identification of recurrence/death risk factors are vital for differentiated thyroid cancer management.
• Older age, male gender, smoking, tumor size, and lymph node status are significant predictors of poor outcomes in DTC.
• These findings underscore the importance of risk factor assessment for optimizing patient care and prognosis in DTC.