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Investigating Serum miRNA Levels in Autistic Children with and without Bipolar Disorder: A Case-Control Study
Hüsna Kaan1, Ali Karayağmurlu2, Canan Küçükgergin3
1Department of Child and Adolescent Psychiatry, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkiye.
Noro Psikiyatri Arsivi
|August 12, 2026
Summary
Children with autism spectrum disorder (ASD) and bipolar disorder (BD) show distinct serum microRNA (miRNA) profiles. Elevated levels of specific miRNAs may serve as biomarkers for early diagnosis and intervention in comorbid ASD and BD.
Area of Science:
- Neuroscience
- Genetics
- Biochemistry
Background:
- Autism spectrum disorder (ASD) and bipolar disorder (BD) comorbidity presents significant clinical challenges.
- Understanding the biological underpinnings of comorbid ASD and BD is crucial for effective management.
Purpose of the Study:
- To compare serum microRNA (miRNA) levels in pediatric patients with ASD with and without comorbid BD.
- To investigate the association between specific miRNAs and BD comorbidity in ASD.
Main Methods:
- Quantitative real-time polymerase chain reactions were used to measure serum miRNA levels.
- The study included pediatric patients diagnosed with ASD and comorbid ASD + BD.
Main Results:
- Patients with ASD + BD exhibited greater ASD severity compared to those with ASD alone.
- Serum levels of miR-134-5p, miR-206, and miR-126-5p were significantly higher in the ASD + BD group.
- miR-134-5p levels correlated with manic episode frequency in the ASD + BD group.
Conclusions:
- Specific miRNAs may play a role in the pathophysiology of comorbid BD in children with ASD.
- These miRNAs show potential as candidate biomarkers for early diagnosis and intervention.
- Further research is needed to validate findings and elucidate underlying mechanisms.