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The double-edged sword of daptomycin: a case of daptomycin-induced eosinophilic pneumonia

Mohammed Najdat Seijari1, Fayaz Khan1, Taraneh Zamani1

  • 1Department of Internal Medicine, Good Samaritan Hospital, TriHealth, 375 Dixmyth Ave, Mount Auburn neighborhood, Cincinnati, OH 45220, United States.

Oxford Medical Case Reports
|August 12, 2026
PubMed

Insights

Daptomycin can rarely cause daptomycin-induced eosinophilic pneumonia (DIEP), a serious lung condition. Early recognition and stopping daptomycin quickly can resolve symptoms without further treatment.

Area of Science:

  • Infectious Diseases
  • Pulmonology
  • Pharmacology

Background:

  • Daptomycin is a crucial antibiotic for treating resistant Gram-positive infections like MRSA and VRE.
  • Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare but serious adverse effect.
  • Prompt diagnosis and management of DIEP are essential to prevent morbidity.
Keywords:
Antibiotic toxicityDaptomycinDrug-induced lung diseaseEosinophilic pneumonia

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