Mechanisms of LARP7 in regulating the progression of non-small cell lung cancer
Jinfeng He1, Changlian Li1, Linxin Liu1
1Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, Hefei, China.
Background:
La ribonucleoprotein domain family member 7 (LARP7) is an RNA-binding protein that belongs to the LARP family, acting as a tumor suppressor in multiple cancers. However, the role of LARP7 in lung cancer cell bio-behaviors and the underlying mechanisms are not well clarified. This study aims to investigate the role of LARP7 in regulating lung cancer phenotypes and its association with non-small cell lung cancer (NSCLC).
Methods:
In this study, we first utilized public databases to assess the expression of LARP7 in lung cancer, then explored the effects of LARP7 on tumor growth, as well as the proliferation, migration, invasion, and apoptosis of lung cancer cells, and further investigated the possible mechanisms by which LARP7 regulates lung cancer progression.
Results:
The results revealed that the expression of LARP7 was low in lung cancer tissues. Further experiments showed that overexpression of LARP7 significantly inhibited the proliferation, migration, and invasion, as well as promoting apoptosis of lung cancer cells in vitro, and inhibited tumor growth in vivo. Mechanistically, single-cell RNA-sequencing analysis revealed that LARP7 overexpression upregulated specific splice variants of FN1 and ADAR in NSCLC cells.
Conclusions:
The results provide new insights and theoretical support for identifying molecular targets for the diagnosis, prognosis prediction, and treatment of NSCLC.
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