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Nanomaterial-Enabled Fiber-Optic SPR Biosensor for Continuous and Noninvasive Body Fluid Monitoring:Progress and
Wenhan Ma1, Zhilai Zhang1, Jiayang Wang1
1School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian 116024, China.
Nanomaterials (Basel, Switzerland)
|August 12, 2026
Summary
Nanomaterial-enhanced fiber-optic SPR biosensors offer a promising solution for continuous body fluid monitoring, overcoming limitations of current technologies for personalized healthcare and wearable diagnostics.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Analytical Chemistry
Background:
- Continuous, noninvasive body fluid monitoring is crucial for personalized healthcare and chronic disease management.
- Fiber-optic surface plasmon resonance (SPR) biosensors offer label-free, real-time detection with miniaturization.
- Existing SPR interfaces face challenges in accuracy, signal sensitivity, and stability for wearable applications.
Purpose of the Study:
- To review recent advancements in nanomaterial-enabled fiber-optic SPR biosensors for continuous body fluid monitoring.
- To highlight how nanomaterials enhance SPR performance for improved sensing capabilities.
- To analyze material strategies and device architectures for various body fluid samples.
Main Methods:
- Review of nanomaterial-mediated electromagnetic field enhancement and plasmonic mode regulation.
- Analysis of nanomaterial functions in interfacial recognition, analyte enrichment, and antifouling.
- Systematic examination of sensing targets, materials, and device designs for tears, urine, saliva, sweat, and breath condensate.
Main Results:
- Nanomaterials significantly improve local electromagnetic fields and plasmonic modes for enhanced SPR sensing.
- Engineered interfaces provide improved analyte recognition, enrichment, and transport.
- Strategies for antifouling and flexible integration enable continuous wearable operation.
Conclusions:
- Nanomaterial-enabled fiber-optic SPR biosensors represent a significant advancement for reliable, continuous body fluid monitoring.
- Further research is needed to address challenges in real-sample validation and wearable integration.
- These platforms hold great potential for future point-of-care diagnostics and personalized health management.
