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Updated: Aug 14, 2026

LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics
08:01

LERLIC-MS/MS for In-depth Characterization and Quantification of Glutamine and Asparagine Deamidation in Shotgun Proteomics

Published on: April 9, 2017

A Combined Experimental-Theoretical Approach Unveils the Comprehensive Asn Deamidation Kinetics

Maria Laura De Sciscio1, Rosanna Mosetti2, Annalisa D'Arco2

  • 1Department of Chemistry, University of Rome, Sapienza, P.le A. Moro 500185Rome, Italy.

Journal of the American Chemical Society
|August 12, 2026
PubMed
Summary

Researchers revealed the deamidation mechanism of Asparagine (Asn) residues using experimental and computational methods. This study clarifies the reaction kinetics and pH dependence, crucial for advancing biologic drug development.

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