Related Experiment Videos
The Portfolio diet and disease outcomes: a systematic review and meta-analysis of observational studies
Vicky Wai Ki Chan1, Gebretsadkan Gebremedhin Gebretsadik1,2, Michael T H Tse3
1Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, China.
Abstract:
Emerging evidence suggests the Portfolio diet may confer benefits beyond managing hyperlipidemia. This systematic review and meta-analysis evaluated the association between adherence to the Portfolio diet and disease outcomes in observational studies. Four databases were searched through September 2025, and 10 studies consisting of 513,284 participants were included. Data from 4 prospective cohort studies (n = 352,396) were pooled using random-effects models for disease outcomes. Each 1-standard deviation increase in the Portfolio Diet Score (PDS) was associated with a 6% lower risk of cardiovascular disease (CVD) (RR = 0.94, 95% CI: 0.92 to 0.96) and a 10% lower risk of all-cause mortality (RR = 0.90, 95% CI: 0.86 to 0.95). Qualitative synthesis suggested that higher adherence to the Portfolio diet was associated with lower type 2 diabetes (T2D) risk and lower odds of cancer. In conclusion, higher adherence to the Portfolio diet is inversely associated with risks of CVD and mortality, while the favorable associations with T2D and cancer remain preliminary and hypothesis-generating.
Related Concept Videos
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Bioavailability Study Design: Healthy Subjects Versus Patients
Atherosclerosis III: Management
Models of Health Promotion and Illness Prevention II
The agent-host-environment model states that disease results from...
Cancer Survival Analysis
Factors Affecting Illness
For instance, risk factors are connected to illness, disability,...