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Updated: Aug 14, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
Published on: March 3, 2021
Immune regulation by hypothermia: from triggers and mechanisms to therapeutic applications
Xingchao Pan1, Yangyue Ni2, Xiang Li3
1Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou 310024, University of Chinese Academy of Sciences, China.
Abstract:
Although homeotherms maintain a stable core body temperature through the coordinated regulation of multiple physiological systems, various factors can still lead to abnormal body temperature. While the immune-enhancing effects of fever are well understood, research on how low body temperature regulates immunity remains limited. Notably, cold therapy and hypothermia have been used to manage various diseases, including neurological and metabolic disorders. This review provides a comprehensive overview of the causes of hypothermia, its modulatory effects on immunity and underlying mechanisms, and its therapeutic applications in clinical diseases.
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