Related Experiment Video
Updated: Aug 14, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Central Domains of Quality of Life and Their Associated Factors in Patients With Heart Failure: A Network Analysis
Yilin Zhang1, Mei Yang, Huaxue Zhang
1Yilin Zhang, School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China. Mei Yang, School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China. Huaxue Zhang, School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China. Wenjie Sun, School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China. Xiuzhen Fan, School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China.
Background:
The interactions of quality of life domains and their associated factors remain unclear among patients with heart failure.
Objective:
Our aim was to identify the central domains of quality of life and their associated factors in patients with heart failure.
Methods:
We enrolled 216 patients with heart failure from 3 university-affiliated hospitals in this cross-sectional study. Participants completed self-report questionnaires assessing physical symptoms, depressive and anxiety symptoms, social network, and quality of life. Network analysis was applied to examine the network structure.
Results:
The mean total score for physical quality of life was 42.02 ± 7.99, and for mental quality of life was 47.35 ± 6.70. Physical role functioning (weight = 1.09), mental health (weight = 0.92), and vitality (weight = 0.84) played central domains among network structure of quality of life. Additionally, physical role functioning was most strongly negatively connected to physical symptoms (weight = -0.124), mental health was most strongly negatively connected to anxiety symptoms (weight = -0.328), and vitality was most strongly positively connected to social network (weight = 0.131), respectively.
Conclusions:
Physical role functioning, mental health, and vitality are the top 3 central quality of life domains in patients with heart failure. This finding underscores the need for healthcare providers to prioritize these central domains. Given that physical symptoms, anxiety symptoms, and social network are associated with central domains of quality of life, alleviating physical and anxiety symptoms, as well as fostering social network may provide an opportunity to improve quality of life in patients with heart failure.
Related Concept Videos
Pathophysiology of Heart Failure
Heart Failure VII: Nursing Interventions
Heart Failure II: Pathophysiology
Heart Failure III: Clinical Manifestations
Heart Failure I: Introduction
Heart Failure V: Medical Management