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Beyond the Bloodstream: The Impact of Malaria on Red Cell Development

Chhaminder Kaur1, Tamar P Feldman1,2, Elizabeth S Egan1,2,3

  • 11Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA ;

Annual Review of Microbiology
|August 12, 2026
PubMed

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
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Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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