Related Experiment Video

Updated: Aug 14, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
09:57

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

A clinical nomogram for predicting drug-resistant epilepsy and its long-term persistence in children: a cohort study

Ohcheol Kwon1, Yun Sung Nam1, Hyun-Jin Kim1

  • 1Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Seizure
|August 12, 2026
PubMed

Insights

A new nomogram helps predict drug-resistant epilepsy (DRE) in children, identifying key factors like psychiatric disorders and seizure onset. This tool aids in early risk stratification and personalized treatment for pediatric epilepsy.

Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Prediction Modeling

Background:

  • Drug-resistant epilepsy (DRE) affects a significant portion of pediatric epilepsy cases.
  • Accurate prediction and understanding of DRE persistence are crucial for effective management.

Purpose of the Study:

  • To develop and validate a clinical prediction nomogram for identifying pediatric patients at risk of DRE.
  • To identify predictors associated with the long-term persistence of DRE in children.

Main Methods:

  • Retrospective analysis of 4208 pediatric epilepsy patients (0-18 years).
  • Development of a nomogram using LASSO regression and multivariable logistic regression.
  • Internal validation assessed via discrimination, calibration, and decision curve analyses.

Main Results:

  • 33.7% of patients developed DRE; the nomogram showed good predictive performance (validation AUC 0.778).
  • In patients with DRE and ≥5 years follow-up, 65.2% had persistent DRE.
  • Predictors of persistent DRE included psychiatric disorders, daily seizure frequency, early seizure onset, and perinatal hypoxic-ischemic encephalopathy.

Conclusions:

  • The developed nomogram facilitates early risk stratification for pediatric DRE using routine clinical data.
  • Identifying distinct predictors of DRE persistence underscores the heterogeneity of the condition and supports tailored management approaches.
Abstract

Keywords:
Clinical prediction modelLogistic modelsPediatric epilepsyRisk stratification

More Related Videos

Sampling Cerebrospinal Fluid and Blood from Lateral Tail Vein in Rats During EEG Recordings10:46

Sampling Cerebrospinal Fluid and Blood from Lateral Tail Vein in Rats During EEG Recordings

Published on: September 1, 2023

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Dosage Regimen Designs: Nomograms and Tabulations01:23

Dosage Regimen Designs: Nomograms and Tabulations

Nomograms and tabulations are vital tools used by clinicians to design accurate and individualized dosage regimens. These instruments provide a straightforward method for adjusting dosages based on individual patient characteristics, including age, weight, and physiological condition. The foundation of a drug's nomogram is population pharmacokinetic data collected and analyzed using specific models. This data simplifies complex equations, presenting them diagrammatically or tabularly for easy...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...