Uncovering mammalian fertilization dynamics

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In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans
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In Vivo Visualization of Calcium Transients during Fertilization and Early Development in C. elegans

Published on: July 12, 2024

Tianyu Wu1, Lei Wang1

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, State Key Laboratory of Genetic Engineering, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai 200032, China.

Developmental Cell
|August 12, 2026
PubMed

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Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...