Statherin-derived peptides in pellicle engineering: a scoping review

To systematically map and evaluate the available evidence on the effects of statherin-derived peptides on dental pellicle engineering and their potential application as biomimetic agents for improving protection of dental hard tissues.

A scoping review was conducted in accordance with the PRISMA-ScR guidelines. Medline (via PubMed), Scopus, and Web of Science were searched for studies published up to February 2026. Eligible studies investigated pellicles formed from human saliva on flat enamel, dentin, or hydroxyapatite surfaces modified with statherin-derived peptides.

From 823 identified studies, 12 met the inclusion criteria. Treatment with statherin-derived peptides consistently altered pellicle composition by modifying its proteomic profile, although changes in individual proteins varied across studies. Limited evidence suggested reduced biofilm formation and bacterially induced demineralization. Most studies reported improved erosion-protective properties of the pellicle following peptide treatment, although the magnitude of protection varied according to experimental conditions, peptide concentration, and erosion model.

Statherin-derived peptides can selectively modify the pellicle and enhance its protective properties against erosion while also influencing pellicle composition and, to a lesser extent, biofilm formation. However, the available evidence is limited predominantly to experimental studies, and the clinical relevance of these findings remains uncertain. Further clinical studies are needed to establish optimal application protocols and evaluate long-term efficacy.

Statherin-derived peptides showed potential to strengthen the acquired pellicle, improving protection against dental erosion and possibly reducing biofilm formation.