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Statherin-derived peptides in pellicle engineering: a scoping review
João Victor Frazão Câmara1, Anton Schestakow1, Daniella Pilon Muknickas1
1Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, Saarland University, Homburg/Saar, Germany.
Journal of Dentistry
|August 12, 2026
Summary
Statherin-derived peptides can enhance dental pellicle protection against erosion and influence biofilm formation. Further clinical research is needed to confirm their efficacy and optimal application for dental hard tissue protection.
Area of Science:
- Biomaterials Science
- Dental Research
- Proteomics
Background:
- The acquired dental pellicle is crucial for protecting hard tissues.
- Statherin, a salivary protein, plays a role in pellicle formation.
- Statherin-derived peptides are investigated for biomimetic applications.
Purpose of the Study:
- To systematically review evidence on statherin-derived peptides' effects on dental pellicle.
- To evaluate their potential as biomimetic agents for dental hard tissue protection.
Main Methods:
- A scoping review following PRISMA-ScR guidelines.
- Searched Medline, Scopus, and Web of Science databases.
- Included studies on human saliva pellicles on enamel, dentin, or hydroxyapatite modified with statherin peptides.
Main Results:
- 12 studies met inclusion criteria, altering pellicle composition and proteomic profiles.
- Limited evidence suggests reduced biofilm formation and demineralization.
- Most studies reported enhanced pellicle protection against erosion, with variable efficacy.
Conclusions:
- Statherin-derived peptides modify pellicle composition and enhance erosion protection.
- Potential to influence biofilm formation, but clinical relevance is uncertain.
- Further clinical studies are required to establish optimal protocols and long-term efficacy.
