Related Experiment Video
Updated: Aug 14, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Parents' Fear of Hypoglycemia and Its Association With Diabetes Treatment Modality, Management, and Outcomes in Young
Nanna Lind1, Patricia DeCosta2, Lene Lyngsøe1
1Department of Clinical and Translational Research, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark.
Insights
Parental fear of hypoglycemia (FoH) in type 1 diabetes (T1D) management varies within families, with mothers reporting higher levels than fathers. This fear did not correlate with children's glycemic control, suggesting individual assessment is key.
Area of Science:
- Pediatric Endocrinology
- Diabetes Management
- Psychosocial Aspects of Chronic Illness
Background:
- Parental fear of hypoglycemia (FoH) significantly impacts type 1 diabetes (T1D) management in children.
- Understanding FoH is crucial for family well-being and perceived safety.
- This study investigates FoH in parents of young children with T1D.
Purpose of the Study:
- To describe FoH using the Children's Hypoglycemia Index (CHI) in parents of young children with T1D.
- To examine parent-level differences and interparent agreement regarding FoH.
- To explore associations between FoH and clinical parameters, treatment, and glycemic outcomes.
Main Methods:
- Cross-sectional cohort study linking parent questionnaires with clinical and device data.
- Individual and dyadic parent-level analyses, including intraclass correlation coefficients (ICCs) and Bland-Altman analyses.
- Mixed-effects models assessed associations with HbA1c and CGM metrics, adjusted for covariates.
Main Results:
- Mothers reported higher CHI scores than fathers, except for behavioral fear (P < .001-.003).
- Low parental agreement (ICC 0.00-0.38) indicated substantial within-family variability in FoH.
- No significant associations were found between CHI scores and HbA1c, CGM metrics, or child characteristics.
Conclusions:
- FoH levels differ between mothers and fathers, but FoH varies significantly within families.
- Observed FoH did not correlate with glycemic outcomes, though high automated insulin delivery (AID) use limits interpretation.
- Individual assessment of FoH in both parents is recommended for effective T1D management support.
Background:
Parental fear of hypoglycemia (FoH) may influence diabetes management, family well-being, and perceptions of safety in young children with type 1 diabetes (T1D). The aim was to describe FoH among parents of young children with T1D using a validated version of the Children's Hypoglycemia Index (CHI) and to examine parent-level differences, interparent agreement, and associations with clinical parameters, treatment modality, and glycemic outcomes of their children.
Methods:
Cross-sectional cohort linking parent-reported questionnaire data with clinical and device-derived data. Analyses were conducted at the individual parent level and dyadic (parent-pair) level. Parental agreement was assessed using intraclass correlation coefficients (ICCs) and Bland-Altman analyses to evaluate mean differences and variability. Associations with HbA1c and continuous glucose monitoring metrics were analyzed using mixed-effect models adjusted for age, sex, and automated insulin delivery (AID) use.
Results:
Among 135 children (mean age 6.8 ± 2.1 years; HbA1c 6.8% ± 0.7%; 89.6% using AID), mothers reported higher CHI scores than fathers (β = .35- .58, P < .001-.003), except for behavioral fear. The ICC indicated low parental agreements (0.00-0.38), reflecting substantial within-family variability. The Bland-Altman analyses showed higher mean scores among mothers, but wide limits of agreement, indicating inconsistent differences within dyads. No associations were detected between CHI and HbA1c, continuous glucose monitoring (CGM) metrics (time in range [TIR], time below range [TBR]), treatment modality, or child characteristics.
Conclusions:
Although mothers reported higher FoH at the group level, low agreement indicates that FoH varies within families. No association with glycemic outcomes was observed, although interpretations are limited by high AID use and low HbA1c variability. Individual assessment of FoH in both parents may be clinically relevant.
Related Concept Videos
Hypoglycemia
Hypoglycemia and Glucagon
Diabetes Mellitus: Type 2 and Gestational
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type I Diabetes I: Introduction
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...