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Distinct Transposable Element Transcript Patterns in Microglia Across Aging and Alzheimer's Disease

Randy A Grant1,2,3, Rachel L Doser1,2,3, Thomas J LaRocca1,2,3

  • 1Department of Health & Exercise Science, Colorado State University, Fort Collins, Colorado, USA.

Aging Cell
|August 13, 2026
PubMed
Summary

Microglia, brain immune cells, show stable transposable element (TE) transcripts with aging and Alzheimer's disease (AD), unlike other brain cells. TE levels inversely correlate with autophagy, suggesting a unique role in brain health.

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