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Cardiovascular Phenotypes Across Major Cancer Types: Distribution and Association with All-Cause Mortality in a
Bozhidar Krastev1,2, Natalia Spasova1,2, Desislava Somleva1,2
1Department of Emergency Medicine, Medical University of Sofia, 1527 Sofia, Bulgaria.
Diagnostics (Basel, Switzerland)
|August 13, 2026
Summary
Cardiovascular disease profiles vary by cancer type. Structural heart disease was most linked to mortality in cancer patients, with overall cardiovascular burden offering modest additional information.
Area of Science:
- Oncology
- Cardiology
- Epidemiology
Background:
- Cardiovascular comorbidities are common in patients with solid tumors.
- Their distribution across cancer types and impact on mortality are not well-defined.
Purpose of the Study:
- To assess cardiovascular phenotypes in major cancer groups.
- To examine the association between these phenotypes and all-cause mortality.
Main Methods:
- Retrospective cohort study of 2020 adult cancer patients.
- Classified tumors (respiratory, GI, GU, breast, other) and cardiovascular phenotypes (atherosclerotic, cardiometabolic, structural heart disease, thromboembolic).
- Mortality analyzed as a binary outcome using multivariable logistic regression.
Main Results:
- All-cause mortality was 23.3%, varying significantly by tumor type (highest in respiratory cancers).
- Structural heart disease (OR 1.61) and atherosclerotic phenotype (OR 1.42, borderline) were associated with mortality.
- Increased cardiovascular burden correlated with higher mortality odds (OR 1.12 per factor).
Conclusions:
- Cardiovascular profiles differ across cancer types.
- Structural heart disease is a key phenotype associated with mortality in cancer patients.
- Routinely recorded diagnoses can inform mortality risk, but further longitudinal studies are needed.
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