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Updated: Aug 14, 2026
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Dynamic Assessments of Coronary Flow Reserve after Myocardial Ischemia Reperfusion in Mice
Published on: August 25, 2023
Fractional Flow Reserve Measurement Using Dynamic CT Perfusion Imaging in Patients with Heavy Coronary Calcification
Aaron So1,2, Satoshi Nakamura3, Masafumi Takafuji3
1Imaging Program, Lawson Research Institute, London, ON N6A 4V2, Canada.
Diagnostics (Basel, Switzerland)
|August 13, 2026
Summary
A new CT dynamic angiographic imaging (CT-DAI) algorithm accurately measures fractional flow reserve (FFR) in complex coronary artery disease, even with heavy calcification and stents.
Area of Science:
- Cardiovascular Imaging
- Interventional Cardiology
- Medical Diagnostics
Background:
- Coronary artery disease (CAD) assessment is challenging with diffuse calcification and stents.
- Accurate fractional flow reserve (FFR) measurement is crucial for guiding treatment decisions.
Purpose of the Study:
- To evaluate a novel CT dynamic angiographic imaging (CT-DAI) algorithm for FFR measurement.
- To compare CT-DAI derived FFR with the clinical gold standard in patients with complex CAD.
Main Methods:
- Retrospective study of 16 patients with CAD (24 coronary arteries).
- Dynamic CT myocardial perfusion scans with adenosine triphosphate infusion.
- CT-DAI algorithm used to compute FFR from time-enhancement curves.
- Comparison with invasive catheter-based FFR measurements.
Main Results:
- CT-DAI derived FFR showed excellent linear correlation (R=0.974) with invasive FFR.
- 100% sensitivity and specificity for detecting significant coronary stenosis.
- Minimal mean difference (0.004) and narrow limits of agreement between CT-DAI and invasive FFR.
Conclusions:
- CT-DAI can accurately derive FFR in coronary arteries with heavy calcification and stents.
- This non-invasive method shows high diagnostic performance.
- CT-DAI offers a promising alternative for FFR assessment in complex CAD.
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