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Intussusception in Cronkhite-Canada Syndrome
Li Ma1, Ji Li2, Xiaoyin Bai2
1Department of Ultrasound, Peking Union Medical College Hospital, Beijing 100730, China.
Diagnostics (Basel, Switzerland)
|August 13, 2026
Summary
Cronkhite-Canada syndrome, a rare gastrointestinal disorder, presents unusual imaging findings like mucosal thickening and intussusception in adults. These signs, though not unique, are crucial for early diagnosis of this non-hereditary polyposis syndrome.
Area of Science:
- Gastroenterology
- Medical Imaging
- Rare Diseases
Background:
- Cronkhite-Canada syndrome (CCS) is a rare, non-hereditary polyposis syndrome.
- It presents with non-specific gastrointestinal symptoms, alopecia, hyperpigmentation, and nail dystrophy.
- Typical endoscopic findings include diffuse sessile polyps and edematous mucosa.
Purpose of the Study:
- To report an unusual case of Cronkhite-Canada syndrome in an adult.
- To highlight the role of specific imaging findings in suspecting CCS.
- To emphasize the importance of early diagnosis and endoscopic confirmation.
Main Methods:
- Case report of a 44-year-old woman.
- Utilized intestinal ultrasound and CT scans for imaging.
- Confirmed diagnosis via endoscopy.
Main Results:
- Intestinal ultrasound and CT revealed diffuse mucosal thickening.
- An ileocecal intussusception was identified.
- These findings, while not pathognomonic, were highly unusual for an adult patient.
Conclusions:
- Unusual imaging findings such as diffuse mucosal thickening and intussusception can be critical indicators for suspecting Cronkhite-Canada syndrome in adults.
- These red flag signs can prompt timely endoscopic evaluation and diagnosis.
- Early recognition of these atypical presentations aids in managing this rare condition.
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