Related Experiment Video
Updated: Aug 14, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
Published on: October 21, 2017
Metabolic Reprogramming of the Liver by IL-33: A Protective Response to Acute Injury
Ying Wu1, Weinan Gao1, Mengrui He1
1Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China.
Background And Aims:
The glucose metabolism pattern of the liver is closely related to liver diseases. In recent years, alcoholic hepatitis, viral hepatitis, fatty liver and other diseases have become important liver diseases that impact people's lives. IL-33 (interleukin-33), as a member of the IL-1 cytokine family, and "alarmin" play a multi-dimensional regulatory role in various physiological and pathological processes of the liver.
Methods:
This study, by integrating transcriptomic data analysis and in vitro and in vivo experiments, expounds on new insights into the regulation of hepatocyte fate by IL-33 through metabolic reprogramming and reveals the potential, new role of IL-33 as a regulatory factor of metabolism.
Conclusions:
Our research further confirmed that IL-33, in addition to serving as an alarm hormone, is also a key checkpoint for liver metabolism, capable of promoting oxidative phosphorylation in hepatocytes and antagonizing acute liver injury induced by CCl4.
Related Concept Videos
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cirrhosis II: Pathophysiology
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Regulation of the Unfolded Protein Response
