Decentralized Assessment of a Dihydromyricetin- and L-Cysteine-Based Multi-Ingredient Dietary Supplement on...

Background/Objectives: This decentralized, real-world observational cohort study assessed whether Cheers Restore (Houston, TX, USA), a commercially available dietary supplement, is associated with improved next-day subjective well-being (energy, mental clarity, physical well-being, and sleep quality) following alcohol consumption in healthy adults. A secondary aim evaluated the feasibility of integrating consumer wearables into future controlled studies. Methods: Ninety adults (56% female; mean age 44.4 years) were enrolled via the Alethios digital research platform and contributed 2958 morning surveys across three self-selected behavioral conditions: Alcohol-Only (reference), Cheers Restore, and Non-Drinking Baseline. Four subjective outcomes (energy, mental clarity, physical well-being, sleep quality rating; 1-10 scale) were modeled using linear mixed-effects models with random intercepts for participant and centered drink count as a covariate. Results: Cheers Restore use was associated with statistically significant improvements across all four subjective outcomes relative to alcohol-only nights: mental clarity (β = 0.356, 95% CI 0.214-0.499, p < 0.001), physical well-being (β = 0.335, 95% CI 0.189-0.482, p < 0.001), energy (β = 0.270, 95% CI 0.133-0.407, p < 0.001), and sleep quality rating (β = 0.263, 95% CI 0.096-0.430, p = 0.002). Standardized effect sizes were small (Cohen's d = 0.20-0.32). Paired Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) analysis confirmed stable consumption with no evidence of increased alcohol consumption over the short, self-reported follow-up. Conclusions: In this observational cohort, Cheers Restore use was associated with consistent improvements in next-day subjective well-being. These findings warrant a randomized, placebo-controlled trial to establish causality. ClinicalTrials.gov: NCT07069608, registered 16 July 2025.