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Microbiome-Directed Bioactive Strategies in Skin Aging: Mechanistic Insights and Precision Nanocarrier Delivery

Beatrice Bălăceanu-Gurău1, Ina Sotiri2, Patricija Girštautė3

  • 1Ph.D. Doctoral School, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Molecules (Basel, Switzerland)
|August 13, 2026
PubMed

Insights

Targeting the skin microbiome with bioactive compounds and advanced delivery systems shows promise for delaying skin aging and restoring skin health. This approach addresses key aging factors like inflammation and oxidative stress.

Area of Science:

  • Dermatology and Aging Research
  • Microbiome Science
  • Biotechnology

Background:

  • Skin aging is a complex process influenced by intrinsic factors, environmental exposures, and physiological changes.
  • The endocrine-microbiome-skin axis plays a crucial role in maintaining skin homeostasis during aging.
  • Dysbiosis and impaired skin barrier function are key hallmarks of aged skin.

Purpose of the Study:

  • To review the current evidence on the endocrine-microbiome-skin axis in aging.
  • To evaluate microbiome-directed bioactive strategies for skin aging.
  • To examine advanced delivery platforms for enhancing bioactive compound efficacy.

Main Methods:

  • Literature review integrating evidence on the endocrine-microbiome-skin axis.
  • Analysis of microbiome-directed bioactives (probiotics, prebiotics, etc.) and their mechanisms.
  • Evaluation of advanced delivery systems (liposomes, nanoparticles, etc.).

Main Results:

  • Microbiome-directed bioactives influence collagen homeostasis, mitochondrial function, barrier integrity, and immune regulation.
  • Advanced delivery platforms enhance compound stability, skin retention, and targeted release.
  • Key mechanisms involve microbial metabolite signaling and systemic endocrine-metabolic status.

Conclusions:

  • Microbiome-directed bioactive compounds combined with precision delivery systems offer a promising strategy for mitigating skin aging.
  • Further research is needed to address translational limitations, including personalization and long-term safety.
  • This evolving strategy aims to delay skin aging and restore cutaneous homeostasis.
Keywords:
antioxidantsbioactive compoundscosmeceuticalsendocrine–microbiome–skin axisnanocarriersphytoestrogenspostbioticsprecision dermatologyskin agingskin microbiome

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