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Published on: April 15, 2016
Locoregional Therapy Pressure-Enabled Drug Delivery for Liver Cancers
Thomas Eggleston1, Fady Bassem Fayek2, Jacqueline Kowalke3
1Corewell Health Lakeland Hospitals-St. Joseph's Hospital, St. Joseph, MI 49085, USA.
Cancers
|August 13, 2026
Summary
Pressure-enabled drug delivery (PEDD) offers improved cancer treatment in the liver by enhancing drug penetration. This advanced locoregional therapy shows promise for future oncologic treatments.
Area of Science:
- Oncology
- Interventional Radiology
- Drug Delivery Systems
Background:
- Hepatic malignancies like HCC are a major cause of cancer mortality.
- Most liver cancer patients are diagnosed at advanced stages, making surgery unsuitable.
- Locoregional therapies (LRTs) are crucial for managing unresectable liver tumors.
Purpose of the Study:
- To review current evidence on pressure-enabled drug delivery (PEDD) for liver cancer.
- To contextualize PEDD within the landscape of liver cancer locoregional therapies.
- To evaluate the potential of PEDD in improving oncologic outcomes.
Main Methods:
- This is a narrative review synthesizing existing preclinical and clinical data.
- The review focuses on catheter-directed therapies for hepatic malignancies.
- It specifically examines pressure-enabled drug delivery (PEDD) techniques.
Main Results:
- Conventional catheter infusion is limited by particle escape and high tumor pressure, hindering drug delivery.
- PEDD, using balloon-occlusion or microvalve catheters, overcomes these limitations.
- Early data suggest PEDD improves drug delivery, has a good safety profile, and may support immunotherapy.
Conclusions:
- PEDD is a promising advancement in catheter-based liver cancer therapy.
- It demonstrates potential for enhanced drug penetration and regional immunotherapy.
- Further randomized trials are needed to confirm PEDD's superiority over conventional methods.
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