Related Experiment Video
Updated: Aug 14, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
Neoadjuvant Treatment Including Targeted Therapy and Locoregional Interventions for Locally Advanced Thyroid Cancer:
Tz-You Chen1, Lay-San Lim1, Yen-Hao Chen2
1Department of Endocrinology and Metabolism, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Cancers
|August 13, 2026
Summary
Neoadjuvant therapy combining targeted drugs and local interventions shows promise for advanced thyroid cancer, potentially improving surgical outcomes and reducing tumor burden in select patients.
Area of Science:
- Oncology
- Surgical Oncology
- Radiology
Background:
- Locally advanced thyroid cancer presents significant challenges with poor prognosis and high surgical risks.
- Neoadjuvant treatment strategies are being explored to improve outcomes for these complex cases.
Purpose of the Study:
- To assess the feasibility and outcomes of neoadjuvant treatment for locally advanced thyroid cancer.
- To evaluate the impact of targeted therapy and locoregional interventions on surgical resection and morbidity.
Main Methods:
- Retrospective analysis of 17 patients with locally advanced thyroid cancer.
- Neoadjuvant treatment included tyrosine kinase inhibitors (TKIs), transarterial embolization (TAE), and radiofrequency ablation (RFA).
- Outcomes assessed included R0/R1 resection rates, tumor response (RECIST v1.1), and surgical complexity scores (MMM, Invasive Thyroid Class).
Main Results:
- Five patients (29%) achieved R0/R1 resection, with four achieving R0.
- Objective response rate was 47%, and 12-month progression-free survival was 58.2%.
- Significant reductions in tumor burden and surgical complexity were observed, indicated by improved MMM and Invasive Thyroid Class scores.
Conclusions:
- Neoadjuvant therapy may enhance tumor downstaging and surgical feasibility in patients with initially unresectable thyroid cancer.
- This approach shows potential for improving outcomes in select advanced thyroid cancer cases.
- Further prospective research is necessary to confirm these preliminary findings.
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