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Adult Sarcomas with NTRK Fusions: Clinicopathologic and Genomic Heterogeneity

Michael Schwartz1,2, Kieran Sweeney3, Steven C Smith4

  • 1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Cancers
|August 13, 2026
PubMed
Summary

Adult sarcomas with NTRK gene fusions are rare and diverse. Understanding their genomic context is crucial for effective TRK inhibitor therapy, as fusion status alone may not predict oncogenic dependence.

Keywords:
NTRK gene fusionsNTRK-rearranged sarcomasTRK inhibitorsfusion-driven tumorsnext-generation sequencingprecision oncologysarcoma genomics

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