Integrated Systemic and Neurobiological Effects of a Multi-Form Magnesium Supplement Compared to Single Magnesium...

Area of Science:

• Neurobiology
• Biochemistry
• Pharmacology

Background:

• Magnesium is vital for physiological and neurobiological functions.
• The specific biological impacts of different magnesium forms are not fully understood.

Purpose of the Study:

• To compare the systemic and neurobiological effects of a multi-form magnesium supplement (Mg BT™) against common single-form magnesium compounds (oxide, citrate, glycinate) in a rat model.
• To evaluate magnesium distribution, metabolic and synaptic markers, gene expression, behavior, and organ histology.

Main Methods:

• Male Wistar rats received daily gastric gavage of Mg BT™ or individual magnesium compounds (50 mg/kg/day elemental Mg) for 30 days.
• Evaluated endpoints included serum/tissue magnesium levels, glucose tolerance, synaptic proteins (synaptophysin, PSD95, drebrin), gene expression (NR2B, BDNF), behavior, and liver/kidney histology.

Main Results:

• Multi-form magnesium increased serum magnesium without altering glucose homeostasis.
• It modulated synaptic plasticity proteins and induced mild anxiolytic-like effects, with no changes in locomotion.
• No adverse histological findings were noted; renal CLDN-19 expression was preserved, indicating tubular integrity.

Conclusions:

• Supplementation with the multi-form Mg BT™ influenced systemic, behavioral, and molecular parameters in rats.
• Its effects were comparable to individual magnesium compounds under the tested conditions.
• The findings suggest Mg BT™ impacts multiple biological domains without causing adverse effects.