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Lack of Association Between MIR155 Gene Variant rs767649 and Risk for Parkinson's Disease

Hortensia Alonso-Navarro1, Sofía Ladera-Navarro2, Pedro Ayuso2

  • 1Section of Neurology, Hospital Universitario del Sureste, 28500 Arganda del Rey, Spain.

International Journal of Molecular Sciences
|August 13, 2026
PubMed

Insights

This study investigated the association between a specific genetic variant (rs767649) in the MIR155 gene and Parkinson's disease (PD) risk. No significant link was found between this variant and PD in the studied Spanish population.

Area of Science:

  • Neuroscience
  • Genetics
  • Immunology

Background:

  • Neuroinflammation is implicated in Parkinson's disease (PD) pathogenesis.
  • MicroRNAs (miRNAs), such as miR-155, play a role in neuroinflammation.
  • A prior study suggested a link between the MIR155 gene variant rs767649 and PD risk.

Purpose of the Study:

  • To replicate the association between the MIR155 gene variant rs767649 and Parkinson's disease risk.
  • To analyze genotype and allele frequencies in a larger Spanish population.
  • To investigate the relationship between the variant and age at PD onset.

Main Methods:

  • Case-control study involving 459 PD patients and 460 healthy controls from Spain.
  • Genotyping of the MIR155 rs767649 single nucleotide variant (SNV) using TaqMan assay.
  • Analysis of genotype and allele frequencies under various inheritance models.

Main Results:

  • No statistically significant differences in genotype or allele frequencies of rs767649 were observed between PD patients and controls.
  • The age at PD onset did not differ across the MIR155 rs767649 genotypes.
  • The study did not find a significant association between MIR155 rs767649 variants and PD risk in this cohort.

Conclusions:

  • The MIR155 rs767649 variant is not significantly associated with Parkinson's disease risk in the studied Spanish population.
  • Limited statistical power due to low variant allele frequency means modest genetic effects cannot be ruled out.
  • Further research with larger cohorts may be needed to fully elucidate the role of MIR155 variants in PD.
Keywords:
MIR155 geneParkinson’s diseasegeneticspolymorphismsrisk-factors

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