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Alcohol Consumption and Gut Microbiota-Derived Metabolites in Primates: A Systematic Review
Yenny Trinidad Fierro-Salgado1, Manuel Reiriz1, Javier Calleja-Conde1
1Basic and Clinical Neuroscience Research Group (NBC), School of Life and Nature Sciences, Nebrija University, 28240 Madrid, Spain.
Alcohol consumption alters gut microbiota metabolites, reducing short-chain fatty acids and changing amino acid pathways. Abstinence may partially restore these changes, suggesting biomarkers for alcohol-related conditions.
Area of Science:
- Microbiome research
- Metabolomics
- Alcohol-related pathophysiology
Background:
- Alcohol consumption is linked to gut microbiota changes, but metabolite data is fragmented.
- Understanding these metabolites is crucial for alcohol-related disease mechanisms.
Purpose of the Study:
- To systematically review alcohol's effects on gut microbiota-derived metabolites in humans and non-human primates.
- To identify key metabolites and pathways affected by alcohol exposure.
Main Methods:
- Systematic review following PRISMA guidelines (2012-2026).
- Searches in PubMed, Web of Science, Scopus, and ScienceDirect.
- Quality assessment using Newcastle-Ottawa Scale and SYRCLE Risk of Bias tool.
Main Results:
- Alcohol consistently altered metabolomics across matrices, reducing short-chain fatty acids and tryptophan metabolites.
- Changes observed in phenolic compounds, hippuric acid, bile acids, and purine metabolism.
- Microbial diversity findings were heterogeneous; some studies noted reduced *Faecalibacterium* and butyrate producers.
Conclusions:
- Alcohol consumption significantly alters multiple gut microbiota metabolic pathways.
- Identified metabolites may play a role in alcohol-related diseases and serve as biomarkers.
- Partial recovery of microbial and metabolomic profiles observed with abstinence.
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