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Current Advances in the Physiological Roles and Disease-Associated Mechanisms of ADAMTS16

Linxiu Wang1, Jiazhen Zhang1, Yuying Zhang1

  • 1School of Biological Science and Technology, University of Jinan, Jinan 250022, China.

International Journal of Molecular Sciences
|August 13, 2026
PubMed

Insights

ADAMTS16, a key protein in the ADAMTS family, regulates extracellular matrix components. This review details its varied roles in development and diseases, highlighting tissue-specific expression and functions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • ADAMTS16 (a disintegrin and metalloproteinase with thrombospondin motifs 16) is a crucial enzyme involved in extracellular matrix (ECM) remodeling.
  • Its dysregulation is implicated in various physiological and pathological processes.

Purpose of the Study:

  • To systematically review the expression profiles and diverse roles of ADAMTS16.
  • To elucidate its mechanisms of action across different tissues and conditions.

Main Methods:

  • Literature review of studies on ADAMTS16 expression and function.
  • Analysis of ADAMTS16's involvement in reproductive, cardiovascular, ocular, skeletal, and oncological contexts.

Main Results:

  • ADAMTS16 exhibits distinct expression patterns and functions in various tissues and cell types.
  • It plays significant roles in reproductive development, cardiovascular diseases, ocular diseases, skeletal disorders, and malignancies.
  • ADAMTS16 influences cell proliferation, differentiation, and migration through ECM interactions and cytokine synergy.

Conclusions:

  • ADAMTS16 is a versatile regulator of ECM homeostasis with broad implications in health and disease.
  • Understanding its tissue-specific functions is vital for developing targeted therapeutic strategies.
Keywords:
ADAMTS16TGF-β signalingcancerextracellular matrixreproductive development

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