Prediagnostic Urinary Tract-Related Manifestations and Recurrence Risk in Colorectal Cancer with Bladder Involvement

Area of Science:

• Oncology
• Urology
• Epidemiology

Background:

• Colorectal cancer (CRC) with bladder involvement is a high-risk disease subgroup.
• Urinary tract-related manifestations (UTRMs) often accompany bladder-involved CRC.
• The prognostic value of prediagnostic UTRMs in this population is not well understood.

Purpose of the Study:

• To investigate the association between prediagnostic UTRMs and oncologic outcomes in patients with bladder-involved CRC.
• To determine if UTRMs predict disease recurrence or mortality in this specific patient cohort.

Main Methods:

• Population-based retrospective cohort study (2000-2020) using national health databases.
• Included 2608 patients diagnosed with bladder-involved CRC.
• Identified prediagnostic UTRMs (e.g., frequency, dysuria, UTIs) within 6 months before CRC diagnosis; used weighted Cox models for analysis.

Main Results:

• Patients with prediagnostic UTRMs showed a significantly higher risk of disease recurrence (adjusted HR 1.57).
• UTRMs requiring antibiotic treatment were associated with a substantially greater recurrence risk (adjusted HR 4.17), though with caution due to sample size.
• No significant association was found between UTRMs and CRC-specific mortality.

Conclusions:

• Prediagnostic UTRMs are associated with an increased risk of recurrence in patients with bladder-involved CRC.
• These clinical findings may offer valuable supplementary information for postoperative surveillance strategies.
• Further research is needed to confirm these associations and their clinical utility.