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Amb a 1-Specific IgE in Heart Failure: A Translational Framework for Seasonal Risk, Endotyping, and Patient-Centered
Camelia-Felicia Bănărescu1,2, Octavia Harich1,3, Cristina Uța1,2,4
1Center of Immuno-Physiology and Biotechnologies, Department of Functional Sciences, "Victor Babeș" University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Journal of Clinical Medicine
|August 13, 2026
Summary
Ragweed allergen Amb a 1-specific IgE may indicate a heart failure subtype vulnerable during allergy season. However, current evidence does not support its use for diagnosing or treating heart failure.
Area of Science:
- Cardiology
- Allergology
- Immunology
Background:
- Amb a 1 is the primary allergen in ragweed pollen, a marker for ragweed sensitization.
- Heart failure is a complex syndrome influenced by immune responses, endothelial function, and environmental factors.
Purpose of the Study:
- To review evidence linking Amb a 1-specific IgE, allergic inflammation, and cardiovascular remodeling in heart failure.
- To explore the potential role of ragweed sensitization in heart failure phenotypes.
Main Methods:
- A targeted narrative review of component-resolved diagnostics, IgE signaling, allergic inflammation, and heart failure pathophysiology.
- Integration of evidence on pollen exposure and cardiovascular inflammation.
Main Results:
- No studies confirm Amb a 1-specific IgE as a heart failure biomarker.
- Plausible links exist between IgE responses and cardiovascular dysfunction via inflammation and endothelial effects.
- Amb a 1-specific IgE might identify heart failure patients vulnerable during ragweed season, especially those with allergic conditions.
Conclusions:
- Amb a 1-specific IgE is not currently validated for inferring cardiac causality or guiding heart failure treatment.
- Further research is needed to clarify the clinical significance of ragweed sensitization in heart failure management and risk stratification.
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