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Patient-Reported Visual Function and Vision-Related Quality of Life Across Ophthalmic Diseases: An Exploratory
Kenji Kashiwagi1, Syowta Fukuba2, Hiroshi Kasai1
1Department of Ophthalmology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo City 409-3898, Japan.
Journal of Clinical Medicine
|August 13, 2026
Summary
Patient-reported outcomes (PROs) capture subjective visual function beyond clinical measures. Perceived vision change after treatment is linked to quality of life, not just visual acuity.
Area of Science:
- Ophthalmology
- Patient-Reported Outcomes Research
- Quality of Life Studies
Background:
- Conventional clinical measures inadequately capture subjective visual function.
- Patient-reported outcomes (PROs) offer valuable insights into visual experiences.
- This study explores PROs across diverse ophthalmic conditions.
Purpose of the Study:
- Evaluate item-level responses of a novel 11-item questionnaire.
- Assess the association between PROs and vision-related quality of life.
- Examine PRO associations across various ophthalmic diseases.
Main Methods:
- Cross-sectional study of 262 participants with conditions like glaucoma, AMD, DR, RP, and cataracts.
- Participants completed an 11-item PRO questionnaire and the VFQ-25.
- Statistical analyses included correlation, multivariable regression, and ordinal logistic models.
Main Results:
- Perceived vision change after treatment (A6) showed consistent associations.
- A6 correlated with age and negatively with VFQ-25 composite score.
- Visual acuity did not correlate with questionnaire domains, unlike perceived vision change.
Conclusions:
- Item-level PRO responses are complex and not solely explained by visual acuity.
- Patient-perceived visual change offers complementary data on vision-related quality of life.
- Further research with validated instruments is recommended.
