Interventional Mitral Valve Edge-to-Edge Repair in Patients Above 85 Years of Age

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A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Florian Jürgens1, Florian Schindhelm1, Mohammed Abusharekh1

  • 1Clinic of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany.

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|August 13, 2026
PubMed
Abstract

Insights

Mitral valve transcatheter-edge-to-edge repair (M-TEER) is safe and effective for patients aged 85 and older with severe mitral regurgitation. Outcomes and mid-term prognosis were similar to younger patients, demonstrating M-TEER

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Medical Devices

Background:

  • Mitral valve transcatheter-edge-to-edge repair (M-TEER) is a standard treatment for severe mitral regurgitation (MR) in high-risk patients.
  • Elderly patients, particularly those aged 85 years and older, are often excluded from clinical studies despite being a common demographic for M-TEER.

Purpose of the Study:

  • To compare procedural characteristics and outcomes of M-TEER in patients aged 85 years and older versus those younger than 85.
  • To evaluate the safety and efficacy of the PASCAL device in elderly patients undergoing M-TEER.

Main Methods:

  • Retrospective analysis of consecutive patients with severe MR who underwent M-TEER using the PASCAL device (2019-2024).
  • Patients were stratified into two groups: < 85 years and ≥ 85 years.
  • Comparison of baseline characteristics, procedural data, and short- to mid-term outcomes.

Main Results:

  • 71 patients aged ≥ 85 years (mean age 87.0 years) and 304 patients aged < 85 years (mean age 75.5 years) were included.
  • Patients ≥ 85 years had more severe MR and higher STS scores at baseline.
  • No device-related complications were observed in either group. Residual MR at 90 days and overall mortality were comparable between the age groups.
  • No deaths occurred within 30 days in the ≥ 85 years group.

Conclusions:

  • M-TEER with the PASCAL device is safe and effective in patients aged 85 years and older with severe MR.
  • Procedural outcomes and mid-term prognosis for M-TEER in octogenarians are similar to those in younger patient cohorts.
  • This study supports the use of M-TEER in very elderly patients who are often excluded from clinical trials.
Keywords:
M‐TEERPASCALelderlyinterventional cardiologymitral regurgitationstructural hearttranscatheter edge‐to‐edge therapy

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