Related Experiment Video
Updated: Aug 14, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
Lurasidone hydrochloride-loaded microparticle-based long-acting injectable: formulation optimisation,
Gaurav Awasthi1, Parth Patel1, Keerti Jain1
1Drug Delivery and Nanomedicine Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER) - Raebareli, Lucknow, India.
None:
Lurasidone hydrochloride is a promising antipsychotic agent. The currently marketed formulation (Latuda®) of lurasidone hydrochloride exhibits extremely poor bioavailability and requires daily dosing. Current research focuses on the development and optimisation of a lurasidone hydrochloride-loaded poly(lactic-co-glycolic acid) microparticle-based long-acting depot formulation. The optimised batch of microparticles showed 32.81 ± 1.46 µm particle size, 95.74 ± 3.19% an entrapment efficiency, and a drug loading of 27.68 ± 0.95%. The morphological examination showed the buckling effect on the surface of microparticles, resembling the appearance of a golf ball, and DSC revealed amorphisation and successful encapsulation of lurasidone hydrochloride. The in vitro release study was performed for real-time and accelerated conditions, which showed the triphasic drug release pattern and followed the Hixon-Crowell release kinetic model. The real-time study showed 80.26 ± 3.84% drug release within 90 days. Overall, the results of this research work furnished a strong basis for further development of lurasidone hydrochloride microparticle-based long-acting injectables at a large scale.
Related Concept Videos
Modified-Release Drug Delivery Systems: Rate-Programmed I
Modified-Release Drug Delivery Systems: Rate-Programmed II
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Modified-Release Drug Delivery Systems: Drug Release Characteristics
Modified-Release Drug Delivery Systems: Bioavailability
Modified-Release Drug Delivery Systems: Overview

