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Updated: Aug 14, 2026
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Drug-Induced Sleep Endoscopy in Infants With Obstructive Sleep Apnea: Current Evidence and Knowledge Gaps
Melissa Bouhraoua1, Christophe Salois2, Mathieu Bergeron3,4
1Faculty of Medicine, Université de Montréal Montreal Quebec Canada.
Laryngoscope Investigative Otolaryngology
|August 13, 2026
Summary
Drug-induced sleep endoscopy (DISE) in infants with obstructive sleep apnea (OSA) can identify multilevel airway obstruction, guiding interventions. However, evidence is limited, necessitating standardized prospective studies for better outcomes.
Area of Science:
- Pediatric Otolaryngology
- Sleep Medicine
- Diagnostic Endoscopy
Background:
- Obstructive sleep apnea (OSA) in infants presents diagnostic challenges.
- Drug-induced sleep endoscopy (DISE) is increasingly used to evaluate airway obstruction during sleep.
Purpose of the Study:
- To synthesize evidence on drug-induced sleep endoscopy (DISE) in infants with obstructive sleep apnea (OSA).
- To identify common sites of obstruction, management decisions, outcomes, safety, and reporting limitations of DISE in this population.
Main Methods:
- Scoping review following PRISMA-ScR guidelines.
- Searched PubMed, MEDLINE, Embase, and Google Scholar for relevant studies.
- Included 8 observational studies (151 infants) published between 2013-2024.
Main Results:
- DISE identified multilevel obstruction, primarily supraglottic and retrolingual.
- Interventions included supraglottoplasty, adenoidectomy/tonsillectomy, and rarely tracheostomy.
- Postoperative polysomnography (PSG) showed improved apnea-hypopnea index (AHI) from ~10.6 to 3 events/h.
Conclusions:
- DISE is feasible in infants with OSA, revealing dynamic, multilevel obstruction.
- Current evidence is limited by small studies and inconsistent reporting.
- Prospective studies with standardized methods are needed to define optimal outcomes.
