Related Experiment Video
Updated: Aug 14, 2026
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Association between smoking cessation and periodontitis progression: a systematic review and meta-analysis of
Yangyang Xie1, Ya Ma2, Zhen Geng3
1School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.
Aim:
This systematic review and meta-analysis aimed to investigate the association between smoking cessation and periodontitis progression by comparing periodontal outcomes in patients who quit smoking vs. those who continued smoking.
Methods:
PubMed, Embase, and the Cochrane Library were searched for prospective studies (published up to March 2025) on smoking cessation and periodontitis progression, with ≥3 months' follow-up. The primary outcome was probing depth. R Studio 4.1.3 was used for random-effects meta-analyses, sensitivity, and subgroup analyses.
Results:
Six studies (n = 1,934) were included. Smoking cessation was associated with short-term improvements in PD at 3 months (SMD = -1.08, 95%CI = -1.84 to -0.31, P < 0.01) and 6 months (SMD = -1.50, 95%CI = -2.45 to -0.55, P < 0.01), as well as CAL at 3 months (SMD = -0.78, 95%CI = -1.39 to -0.16, P = 0.01). However, these associations were not sustained at 12 months (PD: P = 0.10; CAL: P = 0.27). No significant associations were observed for BOP or PI at any follow-up interval.
Conclusion:
Smoking cessation may be associated with modest short-term improvements in periodontal parameters, particularly PD and CAL. However, further high-quality studies with longer follow-up are warranted to confirm clinical relevance.
Related Concept Videos
01:11Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
01:27The Oral Microbiota
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:26Stress Prevention and Stress Management Techniques IV
01:24Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History