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Updated: Aug 14, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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A destination-driven framework for nanoparticle-enabled targeted protein degradation

Yazhen Wang1,2,3, Xue Xia2, Shengwei Xie1,3

  • 1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.

Acta Pharmaceutica Sinica. B
|August 13, 2026
PubMed
Summary

Targeted protein degradation (TPD) strategies are classified by location: intracellular TPD (iTPD) and extracellular TPD (eTPD). Overcoming the delivery gap requires location-specific nanoplatform design for effective protein elimination.

Keywords:
Drug delivery systemExtracellular protein degradationIntracellular protein degradationLysosomal degradationNanoplatformProteasomal degradationProteostasisTargeted protein degradation (TPD)

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