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Instrumented Three-Dimensional Gait Analysis in an Adult With KIF1A-Associated Neurological Disorder: A Case Report
Ana Rita Pessoa1, Diogo Portugal2, Fábio Pinho1
1Physical and Rehabilitation Medicine Service, Unidade Local de Saúde de São José, Lisboa, PRT.
Cureus
|August 13, 2026
Summary
KIF1A-associated neurological disorder (KAND) presents unique gait abnormalities despite preserved walking speed. Comprehensive 3D gait analysis reveals kinematic, kinetic, and EMG deficits, aiding targeted interventions for this complex condition.
Area of Science:
- Neurology
- Biomechanical Engineering
- Genetics
Background:
- KIF1A-associated neurological disorder (KAND) is a spectrum of neurological conditions caused by KIF1A gene variants.
- KAND often presents as hereditary spastic paraplegia (HSP) with additional symptoms like ataxia and neuropathy.
- Instrumented 3D gait analysis data in KAND patients, especially compared to pure HSP, is limited.
