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Translation, sorting and enrichment: acoustic valve micro robotic system for multifunctional micro manipulation
Xianming Qin1, Yi Ouyang1, Ziyu Guo1
1State Key Laboratory of Electromechanical Integrated Manufacturing of High-performance Electronic Equipments, Xidian University, Xian 710071, China. qinxianming@xidian.edu.cn.
Lab on a Chip
|August 13, 2026
Summary
This study introduces an acoustic valve microrobotic system for precise micro-manipulation of cells. The system enables high-speed cell sorting and enrichment with excellent accuracy and biocompatibility for advanced applications.
Area of Science:
- Biomedical Engineering
- Micro-robotics
- Acoustic Manipulation
Background:
- Precise manipulation of micro-scale targets is crucial for biomedical engineering, diagnostics, and micro-manufacturing.
- Existing methods face challenges in speed, accuracy, and efficiency for complex micro-tasks.
Purpose of the Study:
- To develop and demonstrate a multifunctional acoustic valve microrobotic system for precise micro-manipulation.
- To enable high-speed, accurate manipulation, sorting, and enrichment of cells and microorganisms.
Main Methods:
- Utilized focused surface acoustic wave transducers to create acoustic potential wells for micro-target manipulation.
- Implemented sweeping acoustic fields for direct sorting and enrichment.
- Conducted biocompatibility tests (thermal stability, cell viability) and applied the system to microalgae-based photocatalysis.
Main Results:
- Achieved high-speed manipulation (>1000 μm s⁻¹).
- Demonstrated sub-10 μm navigation accuracy.
- Obtained high sorting/enrichment efficiency ( >90% recovery, 5-10 fold enrichment).
- Verified system biocompatibility and successful application in photocatalytic degradation.
Conclusions:
- The acoustic valve microrobotic system offers versatile and adaptable micro-manipulation capabilities.
- The platform shows significant potential for cell analysis, biological assembly, and environmental remediation.

